HES is a potentially fatal disease with less than 50% reported 10-year survival. Jones (above) is the only child in the U.S. diagnosed with hypereosinophilic syndrome, a form of leukemia. Kobayashi Z(1), Tsuchiya K, Komachi H, Miki K, Yokota O, Arai T, Miake H, Ishizu H, Akiyama H, Mizusawa H. Author information: (1)Department of Neurology and Neurological Science, Graduate School, Tokyo Medical and Dental University, Japan. 10.1016/0165-4608(83)90135-8 [Google Scholar] Background: Hypereosinophilic syndrome (HES) can be fatal, particularly when eosinophils infiltrate vital organs and/or if extensive thrombosis develops. HES is fatal if not treated, hence early intervention and proper medication must be sought. Sakuta R, Tomita Y, Ohashi M, et al. At present, hypereosinophilic syndrome is manageable (but not curable) with proper drugs and chemotherapy. Numagami Y, Tomita T, Murakami K, et al. This case presentation is unusual in its rapidly progressive course leading to sudden death. Hypereosinophilic syndrome is a disorder of unknown cause, characterized by persistent eosinophilia -- sustained overproduction of eosinophils (white blood cells of the immune system) in the bone marrow. Cancer Genet Cytogenet (1983) 8 (3):197–202. Fatal encephalitis in a case of hypereosinophilic syndrome: MRI and autopsy findings. J Clin Neurosci 2008; 15:585. Brain Dev 2007; 29:182. There is no cure. Hypereosinophilic syndrome is a disease that is characterized by extremely high blood eosinophils. Idiopathic hypereosinophilic syndrome complicated by central sinovenous thrombosis. Blast transformation could occur after many years. zen@bg7.so-net.ne.jp Hypereosinophilic syndromes (HESs) are a group of rare disorders characterized by peripheral blood eosinophilia of 1.5 × 10 9 /L or higher and evidence of end organ manifestations attributable to the eosinophilia and not otherwise explained in the clinical setting. This means that the body manufactures too many white blood cells in the bone marrow. L.J. The prognosis in hypereosinophilic syndrome depends on the organ systems involved, disease severity and response to therapy. Due to the large collection of white blood cells in the bone marrow, they start to spill out of the bone marrow and start accumulating in other tissues and in the blood. Hypereosinophilic syndrome is a chronic and progressive disorder that is potentially fatal. Sinus thrombosis in idiopathic hypereosinophilic syndrome causing fatal cerebral haemorrhage. Fatal hypereosinophilia with chromosome 15q- in a patient with multiple primary and familial neoplasms. More on the rare, progressively fatal blood disorder. The outcome of the treatment and organ involvement differ from person to person. Goffman TE, Mulvihill JJ, Carney DN, Triche TJ, Whang-Peng J. Outcomes can vary greatly from one person to the next. AB - Hypereosinophilic syndrome (HES) is a rare disorder that can manifest in various organ systems. In very severe cases, hypereosinophilic syndrome may be fatal, …
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