The sex disparity in the strength of these associations was significant ( and ). MDS is primarily a disease of the elderly (most patients are older than age 65), but MDS can affect younger patients as well. This advantage, of course, was obtained at the cost of generalizing our conclusions to people not 75 years of age and to people living in other geographical areas. What Is the Cause of Low Blood Count in Elderly Patients. A low white blood cell count can be caused by many health conditions including infections, autoimmune diseases (such as lupus and rheumatoid arthritis), or be a side effect of cancer treatment. The WBC count tends to cluster with other established risk factors such as tobacco smoking [14, 18] as well as HDL-cholesterol and triglycerides [9, 13]. Intraindividual versus interindividual variation,”. Lavender oil is often used to treat stress and anxiety and promote sleep (1). A low white blood cell count can signal that an injury or condition is destroying cells faster than they are being made, or that the body is producing too few of them. Multiple observational studies have demonstrated that WBC counts have substantial ability to predict all-cause mortality [1–4, 14], cardiovascular mortality [14, 15], cerebrovascular mortality [7], and cancer mortality [5, 6, 14] as well as incident coronary heart diseases [15, 16]. A low white blood cell count is the decrease in the cells that fight diseases. A low white blood cell count, along with results from other tests, might already indicate the cause of your illness. The principal finding in the present community-based study of 75-year-olds is a considerable long-term prognostic significance of the basic WBC count, especially among women. These HRs were essentially unchanged by adjustment for established risk factors (current smoking, known hypertension, prior myocardial infarction, known diabetes, total cholesterol, high-density lipoprotein cholesterol, and body mass index). The causes of low blood count in elderly patients include underlying diseases such as cancer or kidney failure, says WebMD. Of note, this prognostic ability contrasts with the serum cholesterol’s lack of ability to predict all-cause mortality among the elderly [12]. Of note women with a WBC count in the two lowest tertiles (≤6.4 × 109/L) had a considerably lower cumulative mortality during followup (27%) compared with the mortality among men (62%) in the highest tertile (WBC count ≥6.8 × 109/L). Furthermore, increased WBC count was significantly associated with cardiovascular mortality in both sexes and with noncardiovascular mortality in women. The median WBC count (in 109/L) was 6.3 (interquartile range 5.4–7.2) for men and 5.7 (4.9–6.8) for women, for sex difference. Main Results. A low blood count is diagnosed using a test called a full blood count, where your blood levels are compared with the population average. Higher white blood cell counts increased the risk of dying as did higher C-reactive protein levels. Causes include: Trauma. The authors are also grateful to Mattias Rehn for excellent technical support. Renal insufficiency associated with age is also a cause of low blood count. Low-density lipoprotein cholesterol (LDL-C) was calculated using the Friedewald formula [10]. Background: Elevated white blood cell (WBC) count is a well-known predictor of chronic kidney disease (CKD) progression. Leukopenia: A low white blood cell count. The ranges of the WBC counts (in 109/L) were 3.0–12.0 for men and 2.9–10.6 for women. To help you better understand MDS, it might be helpful to first consider some basics about bone marrow and blood. Table 2 shows the Cox regression analyses of WBC count and all-cause, cardiovascular, and noncardiovascular mortality stratified by sex. The study included 207 men and 220 women comprising 69% of the invited 75-year-olds in a defined geographical area. The sex disparity in the strength of the association between WBC count and other markers was assessed by including the interaction term between sex and WBC count in a regression model with the marker as dependent variable. The study was approved by the research ethics committee of Uppsala University, Sweden, and was conducted in accordance with the Declaration of Helsinki. Göran Nilsson, Pär Hedberg, John Öhrvik, "White Blood Cell Count in Elderly Is Clinically Useful in Predicting Long-Term Survival", Journal of Aging Research, vol. In 1997 a random sample of 618 of the 1,100 inhabitants born in 1922 (i.e., 75 year old) were invited to participate in a cardiovascular health survey. Consequently, clinically established risk factors among middle-aged people may not be applicable to elderly people, whereas other factors, exemplified by the WBC count, may assume greater importance. Viral Infection: Viruses can cause leukopenia by both slowing the function of bone marrow and by killing off white blood cells. Or your doctor may suggest other tests to further check your condition. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. White blood cells, also called leukocytes, are the warriors of the immune system.Mostly produced by bone marrow, white blood cell count will initially rise when the body is attacked by a disease.If the infection is overwhelming, however, white blood cells may be consumed faster than they can be released, leading to a low count. Cox regression analyses of all-cause, cardiovascular, and noncardiovascular mortality according to WBC count stratified by sex (, White Blood Cell Count in Elderly Is Clinically Useful in Predicting Long-Term Survival, Centre for Clinical Research, Västmanland County Hospital, Uppsala University, 721 89 Västerås, Sweden, Department of Clinical Physiology, Västmanland County Hospital, 721 89 Västerås, Sweden, Department of Medicine, Karolinska Institutet, 171 76 Stockholm, Sweden, R. F. Gillum, D. D. Ingram, and D. M. Makuc, “White blood cell count, coronary heart disease, and death: the NHANES I epidemiologic follow-up study,”, M. P. Weijenberg, E. J. M. Feskens, and D. Kromhout, “White blood cell count and the risk of coronary heart disease and all-cause mortality in elderly men,”, C. Ruggiero, E. J. Metter, A. Cherubini et al., “White blood cell count and mortality in the Baltimore Longitudinal Study of Aging,”, S. T. Weiss, M. R. Segal, D. Sparrow, and C. Wager, “Relation of FEV1 and peripheral blood leukocyte count to total mortality. The median WBC count (in 109/L) was 6.3 (interquartile range 5.4–7.2) for men and 5.7 (4.9–6… Androgens are known to help the body manufacture red blood cells. Margolis et al. Evidently, the WBC count has a much stronger prognostic ability with regard to total mortality and cardiovascular mortality than total cholesterol and LDL-C among the elderly. The mean (SD) was 6.36 (1.44) for men and 5.90 (1.46) for women. Over a mean 5.4 year follow-up period, 169 subjects died of vascular causes and 277 of nonvascular causes. This finding might provide clues as to the association between WBC counts and cardiovascular death. We previously reported the poor prognostic value of serum cholesterol in the present population [12]. Introduction. Failure of your bone marrow or other damage done to your bone marrow. It often happens in babies, very young children, or the elderly. The patients can also be suffering from malnutrition. Model 2, which adjusts for the two most significant risk factors, was used for the cardiovascular and noncardiovascular mortality since the relatively few events in these categories did not allow further adjustments. Serum triglycerides, total cholesterol, and high-density lipoprotein cholesterol (HDL-C) were determined enzymatically on an automated analyser system (Hitachi 717, Boehringer Mannheim). A white blood cell. These results confirmed that the hemoglobin concentration, red blood cell count, and hematocrit value decrease in the elderly subjects as they grow older and it may be considered that reduced ingestion of protein is one of the causes of the phenomenon. The PH assumption for categorical variables was assessed by visual inspection of the log (−log(cumulative survival)). Figure 1 shows the Kaplan-Meier curves for all-cause mortality according to sex-specific WBC count tertiles. By means of the Swedish population register, the study cohort was followed for all-cause mortality from the index examination in 1997 until November 1, 2008. Thus, it is not known whether elevated WBC count is involved directly in the pathogenesis of vascular diseases or is merely a risk indicator of other factors causing vascular damage [19]. Our finding of this test’s relatively strong prognostic ability among the elderly is clinically important. Modification of inflammatory reaction owing to the necessity of female acceptance of the genetically different fetal tissue during pregnancy may be one speculative reason for the sex disparity. … … Notably, the followup time for Weijenberg et al.
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